Another Piece of the p27Kip1 Puzzle

نویسنده

  • Philipp Kaldis
چکیده

How extracellular signals communicate with the cell cycle is poorly understood. In this issue, two papers address this problem by reporting phosphorylation of the cyclin-dependent kinase inhibitor p27Kip1 on a tyrosine residue by nonreceptor tyrosine kinases, which decreases p27 stability. This new mechanism could explain how cells enter the cell cycle from a quiescent state.

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عنوان ژورنال:
  • Cell

دوره 128  شماره 

صفحات  -

تاریخ انتشار 2007